Carboprost (Hemabate) is contraindicated in patients with history of which condition?

• A. Diabetes Mellitus.
• B. Asthma or bronchospasm history.
• C. Hypertension.
• D. Kidney Disease.

Answer: (B)

Carboprost (Hemabate) is a prostaglandin F2 alpha analog used to treat postpartum hemorrhage by triggering strong uterine contractions. However, it also can cause bronchoconstriction, which can worsen asthma or provoke bronchospasm rapidly. Because of this risk, it is contraindicated in patients with asthma or a history of bronchospasm. The other conditions listed—diabetes mellitus, hypertension, and kidney disease—do not inherently interfere with carboprost’s mechanism in a way that creates a contraindication, so they do not preclude its use. If a postpartum hemorrhage requires treatment and asthma is a factor, alternatives such as oxytocin or misoprostol are considered safer options.