What role does vitamin C play in postpartum iron therapy?

• A. Vitamin C enhances iron absorption
• B. Vitamin C inhibits iron absorption
• C. Vitamin C has no effect
• D. Vitamin C is contraindicated with iron

Answer: (A)

Vitamin C increases the absorption of non-heme iron, which is the form used in most postpartum oral iron therapies. It does this by acting as a reducing agent, converting ferric iron (Fe3+) to ferrous iron (Fe2+), which is the readily absorbable form in the duodenum. Vitamin C also helps keep iron soluble in the intestinal lumen, supporting uptake through the enterocyte transporter. Timing practical: take the iron pill with a source of vitamin C, such as orange juice or a vitamin C tablet, to maximize absorption. Avoid taking calcium-containing products or antacids at the same time, since calcium can reduce iron absorption. This combination helps iron therapy work more effectively to correct postpartum iron deficiency anemia.